Immunohistochemistry is a technique for identifying cellular
or tissue constituents (antigens)
by means of antigen-antibody interactions,
the site of antibody binding being
identified either by direct labelling of the antibody, or by use of a secondary labelling
method.
In Situ Hybridization techniques allow the demonstration of specific nucleic acid sequences (genes) in their cellular environment.
Above: Human Papillomavirus DNA demonstrated by In Situ
Hybridization (pink)
in epithelial cells identified by indirect immunofluorescence using antibody
against cytokeratin (green)